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Anti-Lipoamide Dehydrogenase/DLD Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

DLD, Dihydrolipoamide dehydrogenase, is a component of the pyruvate dehydrogenase complex, the alpha-ketoglutarate dehydrogenase complex, and the branched-chain alpha-keto acid dehydrogenase complex (BCKD) . DLD is a flavoprotein enzyme that degrades lipoamide, and produces dihydrolipoamide. The DLD gene contains 14 exons. The gene is localized to 7q31-q32. This gene encodes the L protein of the mitochondrial glycine cleavage system. The L protein, also named dihydrolipoamide dehydrogenase, is also a component of the pyruvate dehydrogenase complex, the alpha-ketoglutarate dehydrogenase complex, and the branched-chain alpha-keto acide dehydrogenase complex.

Synonyms

Dihydrolipoyl dehydrogenase, mitochondrial;1.8.1.4; Dihydrolipoamide dehydrogenase; Glycine cleavage system L protein; DLD; GCSL, LAD, PHE3

Gene Name

DLD

Gene ID

1738

UniProt

P09622

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human DLD, different from the related mouse and rat sequences by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Placenta.

Applications

Flow Cytometry

Field of Research

Cell Biology, Cell Cycle, Cell Differentiation, Developmental Biology, Embryogenesis, Lineage Specification, Nervous System Development, Neurogenesis, Neurology Process, Neuroscience, Organogenesis

Purification

Immunogen affinity purified.

Form

Liquid

Function

Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction.

References & Citations

1. Feigenbaum, A. S., Robinson, B. H.The structure of the human dihydrolipoamide dehydrogenase gene (DLD) and its upstream elements.Genomics 17: 376-381, 1993. 2. Sakata, Y., Owada, Y., Sato, K., Kojima, K., Hisanaga, K., Shinka, T., Suzuki, Y., Aoki, Y., Satoh, J., Kondo, H., Matsubara, Y., Kure, S.Structure and expression of the glycine cleavage system in rat central nervous system.Molec. Brain Res. 94: 119-130, 2001. 3. Scherer, S. W., Otulakowski, G., Robinson, B. H., Tsui, L.-C.Localization of the human dihydrolipoamide dehydrogenase gene (DLD) to 7q31-q32.Cytogenet. Cell Genet. 56: 176-177, 1991.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

54177 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Dihydrolipoyl dehydrogenase, mitochondrial

Subcellular Location

Mitochondrion matrix.

Sequence Similarities

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Protein Name

Dihydrolipoyl dehydrogenase, mitochondrial

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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