Anti-Fibroblast growth factor 10 FGF10 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
FGF 10, Fibroblast growth factor 10, is a protein that in humans is encoded by the FGF10 gene.The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF 10 contains 3 exons and spans at least 52.7 kb. By radioactive in situ hybridization, the FGF 10 gene is mapped to 5p13-p12. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts. FGF 10 translocated into urothelial cell nuclei and initiated a signaling cascade that began with the heparin-dependent tyrosine phosphorylation of surface transmembrane receptors.
Synonyms
Fibroblast growth factor 10; FGF-10; Keratinocyte growth factor 2; FGF10
Gene Name
FGF10
Gene ID
2255
UniProt
O15520
Host
Rabbit
Reactivity
Rat, Mouse, Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human FGF10, different from the related mouse and rat sequence by two amino acids.
Clonality
Polyclonal
Applications
Flow Cytometry
Field of Research
Angiogenesis, Cancer, Cardiovascular, Embryonic Stem Cells, Growth Factors, Growth Factors/Hormones, Secreted, Signal Transduction, Stem Cells
Purification
Immunogen affinity purified.
Form
Liquid
Function
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. .
References & Citations
1. Bagai, S., Rubio, E., Cheng, J.-F., Sweet, R., Thomas, R., Fuchs, E., Grady, R., Mitchell, M., Bassuk, J. A.Fibroblast growth factor-10 is a mitogen for urothelial cells.J. Biol. Chem. 277: 23828-23837, 2002. 2. Emoto, H., Tagashira, S., Mattei, M.-G., Yamasaki, M., Hashimoto, G., Katsumata, T., Negoro, T., Nakatsuka, M., Birnbaum, D., Coulier, F., Itoh, N.Structure and expression of human fibroblast growth factor-10.J. Biol. Chem. 272: 23191-23194, 1997. 3. Umemori, H., Linhoff, M. W., Ornitz, D. M., Sanes, J. R.FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain.Cell 118: 257-270, 2004.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
23436 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Fibroblast growth factor 10
Subcellular Location
Secreted .
Sequence Similarities
Belongs to the heparin-binding growth factors family.
Protein Name
Fibroblast growth factor 10 (FGF-10)
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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