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Anti-Carbonic Anhydrase III/CA3 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Carbonic anhydrase III (CA3) is an enzyme that in humans is encoded by the CA3 gene. CA3 is a member of a multigene family (at least six separate genes are known) that encode carbonic anhydrase isozymes. The gene spans 10.3 kb and contains seven exons and six introns. Using a cDNA clone of the CA3 gene in the study of human-rodent hybrids, the gene was mapped to chromosome 8 which carries a cluster of CA genes. CA3 is found in high concentration in muscle. CA3 is used in conjunction with creatine kinase detection of the carrier state for Duchenne muscular dystrophy.

Synonyms

Carbonic anhydrase 3;4.2.1.1; Carbonate dehydratase III; Carbonic anhydrase III; CA-III; CA3

Gene Name

CA3

Gene ID

761

UniProt

P07451

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human CA3, different from the related mouse and rat sequences by two amino acids.

Clonality

Polyclonal

Tissue Specificity

Muscle specific.

Applications

Flow Cytometry

Field of Research

Associated Proteins, Cardiovascular, Cell Biology, Cell Type Markers, Hypoxia

Purification

Immunogen affinity purified.

Form

Liquid

Function

Reversible hydration of carbon dioxide.

References & Citations

1. Edwards, Y. H., Lloyd, J. C., Parkar, M., Povey, S.The gene for human muscle specific carbonic anhydrase (CAIII) is assigned to chromosome 8.Ann. Hum. Genet. 50: 41-47, 1986. 2. Heath, R., Carter, N. D., Jeffery, S., Edwards, R. J., Watts, D. C., Watts, R. L.Evaluation of carrier detection of Duchenne muscular dystrophy using carbonic anhydrase III and creatine kinase.Am. J. Med. Genet. 21: 291-296, 1985. 3. Wade, R., Gunning, P., Eddy, R., Shows, T., Kedes, L.Nucleotide sequence, tissue-specific expression, and chromosome location of human carbonic anhydrase III: the human CAIII gene is located on the same chromosome as the closely linked CAI and CAII genes.Proc. Nat. Acad. Sci. 83: 9571-9575, 1986.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

29557 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Carbonic anhydrase 3

Subcellular Location

Cytoplasm.

Sequence Similarities

Belongs to the Bcl-2 family.

Protein Name

Carbonic anhydrase 3

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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