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Anti-Annexin VI/ANXA6 Antibody Picoband® Fluoro488 Conjugated

Selected Variant

PA1436-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

Annexin A6 (ANXA6) is a member of a family of proteins that bind membrane or cytoskeleton in a Ca (2+) -dependent manner. These proteins are characterized by homologous amino acid sequences that are present in multiple copies in each protein. ANXA6 gene is assigned to 5q32-q34 by use of a cDNA clone to probe genomic DNA from rodent-human somatic cell hybrids and for in situ hybridization.The ANX6 gene is approximately 60 kb long and contains 26 exons. The genomic sequence at the 3-prime end does not contain a canonical polyadenylylation signal.Ca (2+) -dependent binding between CRHSP28 and ANXA6 is required for acinar cell membrane trafficking events and digestive enzyme secretion

Synonyms

Annexin A6;67 kDa calelectrin; Annexin VI; Annexin-6; Calphobindin-II; CPB-II; Chromobindin-20; Lipocortin VI; Protein III; p68; p70; ANXA6; ANX6

Gene Name

ANXA6

Gene ID

309

UniProt

P08133

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Annexin VI, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Form

Liquid

Function

May associate with CD21. May regulate the release of Ca (2+) from intracellular stores.

References & Citations

1. Davies, A. A., Moss, S. E., Crompton, M. R., Jones, T. A., Spurr, N. K., Sheer, D., Kozak, C., Crumpton, M. J.The gene coding for the p68 calcium-binding protein is localized to bands q32-q34 of human chromosome 5, and to mouse chromosome 11.Hum. Genet. 82: 234-238, 1989. 2. Smith, P. D., Davies, A., Crumpton, M. J., Moss, S. E.Structure of the human annexin VI gene.Proc. Nat. Acad. Sci. 91: 2713-2717, 1994. 3. Thomas, D. D. H., Kaspar, K. M., Taft, W. B., Weng, N., Rodenkirch, L. A., Groblewski, G. E.Identification of annexin VI as a Ca (2+) -sensitive CRHSP-28-binding protein in pancreatic acinar cells.J. Biol. Chem. 277: 35496-35502, 2002.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

75873 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Annexin A6

Subcellular Location

Cytoplasm . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Sequence Similarities

Belongs to the annexin family.

Protein Name

Annexin A6

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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