Anti-MIG/CXCL9 Antibody Picoband® Fluoro488 Conjugated

MIG, also known as CXCL9, is a T-cell chemoattractant inducible by gamma interferon that is a member of the CXC chemokine family of cytokines. This gene is mapped to 4q21. It is noted that, although the best-described activities of the chemokines are as chemotactic factors, chemokines also have an effect on T-cell activation, angiogenesis, and HIV infection. While most CXC chemokines are chemotactic for neutrophils, MIG and INP10 are unusual and similar in being CXC chemokines that are chemotactic for lymphocytes and inactive in neutrophils.

C-X-C motif chemokine 9; Gamma-interferon-induced monokine; Monokine induced by interferon-gamma; HuMIG; MIG; Small-inducible cytokine B9; CXCL9; CMK, MIG, SCYB9

Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines. .

Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.

1. Lee HH, Farber JM (1996) . Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine mini-cluster. Cytogenet. Cell Genet. 74 (4) : 255–8. 2. O'Donovan N, Galvin M, Morgan JG (1999) . Physical mapping of the CXC chemokine locus on human chromosome 4. Cytogenet. Cell Genet. 84 (1-2) : 39–42. 3. Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R (1999) . Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3) . J. Invest. Dermatol. 112 (5) : 716–22.