Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-IP10/CXCL10 Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

C-X-C motif chemokine 10 (CXCL10), also known as Interferon gamma-induced protein 10 kDa (IP-10) or small-inducible cytokine B10, is a protein that in humans is encoded by the CXCL10 gene. It is a small cytokine belonging to the CXC chemokine family. The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines. Luster et al. (1987) reported the isolation of an interferon-inducible gene that encodes a 98-amino acid protein called IP10. The chemokine IFN-gamma-inducible protein 10 (IP-10; CXCL10), a CXC chemokine, and its receptor, CXCR3, were found to be overexpressed in lymph node cells of EAMG rats. IP10 inhibits bone marrow colony formation, has antitumor activity in vivo, is a chemoattractant for human monocytes and T cells, and promotes T cell adhesion to endothelial cells.

Synonyms

C-X-C motif chemokine 10;10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Small-inducible cytokine B10; CXCL10 (1-73) ; CXCL10; INP10, SCYB10

Gene Name

CXCL10

Gene ID

3627

UniProt

P02778

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human IP10.

Clonality

Polyclonal

Tissue Specificity

Expressed on activated B-cells.

Applications

Flow Cytometry

Field of Research

Angiogenesis, Cancer, Chemokines, Immunology, Innate Immunity, Invasion/Microenvironment

Purification

Immunogen affinity purified.

Form

Liquid

Function

Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.

References & Citations

1. Luster AD, Unkeless JC, Ravetch JV (1985) . Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature 315 (6021) : 672–6. 2. Luster AD, Jhanwar SC, Chaganti RS, Kersey JH, Ravetch JV (May 1987) . Interferon-inducible gene maps to a chromosomal band associated with a (4;11) translocation in acute leukemia cells. Proc. Natl. Acad. Sci. U.S.A. 84 (9) : 2868–71. 3. Feferman, T., Maiti, P. K., Berrih-Aknin, S., Bismuth, J., Bidault, J., Fuchs, S., Souroujon, M. C.Overexpression of IFN-induced protein 10 and its receptor CXCR3 in myasthenia gravis.J. Immun.174: 5324-5331, 2005.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

10881 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

C-X-C motif chemokine 10

Subcellular Location

Secreted.

Sequence Similarities

Belongs to the intercrine alpha (chemokine CxC) family.

Protein Name

C-X-C motif chemokine 10

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

More Discoveries

Explore Other Products

Browse additional items from our catalog

HighQC™ Canine Bone Marrow Mesenchymal Stem Cell
ABC-SC0048T 1 Vial

HighQC™ Canine Bone Marrow Mesenchymal Stem Cell

Sign In for Pricing
View Details
alpha TubµLin (TUBA4A) Human shRNA Lentiviral Particle (Locus ID 7277)
TL308572V 500 µL Each

alpha TubµLin (TUBA4A) Human shRNA Lentiviral Particle (Locus ID 7277)

Sign In for Pricing
View Details
Mouse Lrrc26 activation kit by CRISPRa
GA213940 1 Kit

Mouse Lrrc26 activation kit by CRISPRa

Sign In for Pricing
View Details
Rat Regulator of microtubule dynamics protein 1, FAM82B ELISA Kit
MBS9337507-01 48 Well

Rat Regulator of microtubule dynamics protein 1, FAM82B ELISA Kit

Sign In for Pricing
View Details
Rat Regulator of microtubule dynamics protein 1, FAM82B ELISA Kit
MBS9337507-02 96 Well

Rat Regulator of microtubule dynamics protein 1, FAM82B ELISA Kit

Sign In for Pricing
View Details
Rat Regulator of microtubule dynamics protein 1, FAM82B ELISA Kit
MBS9337507-03 5x 96 Well

Rat Regulator of microtubule dynamics protein 1, FAM82B ELISA Kit

Sign In for Pricing
View Details