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Anti-Apolipoprotein D/APOD Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Apolipoprotein D (Apo-D) is a protein that in humans, encoded by the APOD gene. Being a member of the alpha (2 mu) -microglobulin superfamily of carrier proteins, Apo-D is also known as lipocalin.The gene has been localized to the p14.2----qter region of human chromosome 3. It is a glycoprotein of estimated molecular weight 33,000 Da. The Apo-D encoded a protein of 169 amino acid residue.It has been detected in human liver, intestine, pancreas, kidney, placenta, adrenal, spleen, and fetal brain tissue. For its features, Apo-D has been a biomarker of androgen insensitivity syndrome (AIS) .

Synonyms

Apolipoprotein D; Apo-D; ApoD; APOD

Gene Name

APOD

Gene ID

347

UniProt

P05090

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Apolipoprotein D.

Clonality

Polyclonal

Tissue Specificity

Expressed in liver, intestine, pancreas, kidney, placenta, adrenal, spleen, fetal brain tissue and tears.

Applications

Flow Cytometry

Field of Research

Growth Factors/Hormones, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

APOD occurs in the macromolecular complex with lecithin- cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.

References & Citations

1. Drayna, D. T., McLean, J. W., Wion, K. L., Trent, J. M., Drabkin, H. A., Lawn, R. M. Human apolipoprotein D gene: gene sequence, chromosome localization, and homology to the alpha-2mu-globulin superfamily. DNA 6: 199-204, 1987. 2. Drayna, D., Fielding, C., McLean, J., Baer, B., Castro, G., Chen, E., Comstock, L., Henzel, W., Kohr, W., Rhee, L., Wion, K., Lawn, R.Cloning and expression of human apolipoprotein D cDNA.J. Biol. Chem.261: 16535-16539, 1986. 3. Appari M, Werner R, Wünsch L, Cario G, Demeter J, Hiort O, Riepe F, Brooks JD, Holterhus PM (June 2009) . Apolipoprotein D (APOD) is a putative biomarker of androgen receptor function in androgen insensitivity syndrome. J. Mol. Med. 87 (6) : 623–32.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

21276 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Apolipoprotein D

Subcellular Location

Secreted.

Sequence Similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein Name

Apolipoprotein D (Apo-D/ApoD)

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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