Anti-HSD17B6 Antibody Picoband® Fluoro488 Conjugated

Hydroxysteroid 17-beta dehydrogenase 6 is an enzyme that in humans is encoded by the HSD17B6 gene. The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. Baker ME et al point out expression of 17beta-HSDs had an important role in the early evolution of the physiological response to androgens and estrogens. Biswas and Russell concluded that 17beta-HSD6 and RoDH play opposing roles in androgen action; 17beta-HSD6 inactivates 3alpha-adiol by conversion to androsterone and RoDH activates 3alpha-adiol by conversion to dihydrotestosterone. The synthesis of an active steroid hormone by back conversion of an inactive metabolite represents a potentially important mechanism by which the steady state level of a transcriptional effector can be regulated.

17-beta-hydroxysteroid dehydrogenase type 6;17-beta-HSD 6;17-beta-HSD6;1.1.1.105;1.1.1.239;1.1.1.62;3-alpha->beta-hydroxysteroid epimerase;3-alpha->beta-HSE; Oxidative 3-alpha hydroxysteroid dehydrogenase; Short chain dehydrogenase/reductase family 9C member 6; HSD17B6; RODH, SDR9C6

Detected in liver and prostate (at protein level) . Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain. .

NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro) . Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro) . Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro) . Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro) . Has retinol dehydrogenase activity towards all-trans-retinol (in vitro) . Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha- androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids. .

1. Baker ME (Feb 2001) . Evolution of 17beta-hydroxysteroid dehydrogenases and their role in androgen, estrogen and retinoid action. Mol Cell Endocrinol 171 (1-2) : 211–5. doi:10.1016/S0303-7207 (00) 00414-7. PMID 11165032. 2. Biswas, M. G., Russell, D. W. Expression cloning and characterization of oxidative 17-beta- and 3-alpha –hydroxysteroid dehydrogenases from rat and human prostate. J. Biol. Chem. 272: 15959-15966, 1997.