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Anti-Stromelysin-2 MMP10 Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

Stromelysin-2 also known as matrix metalloproteinase-10 (MMP-10) or transin-2 is an enzyme that in humans is encoded by the MMP10 gene.Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Synonyms

Stromelysin-2; SL-2;3.4.24.22; Matrix metalloproteinase-10; MMP-10; Transin-2; MMP10; STMY2

Gene Name

MMP10

Gene ID

4319

UniProt

P09238

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human MMP10.

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Angiogenesis, Cancer, Cardiovascular, Cell Biology, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes

Purification

Immunogen affinity purified.

Form

Liquid

Function

Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.

References & Citations

1. Muller D, Quantin B, Gesnel MC, Millon-Collard R, Abecassis J, Breathnach R (July 1988) . The collagenase gene family in humans consists of at least four members. Biochem. J. 253 (1) : 187–92. 2. Jung JY, Warter S, Rumpler Y (1990) . Localization of stromelysin 2 gene to the q22.3-23 region of chromosome 11 by in situ hybridization. Ann. Genet. 33 (1) : 21–3.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

54151 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Stromelysin-2

Subcellular Location

Secreted, extracellular space, extracellular matrix .

Sequence Similarities

Belongs to the peptidase M10A family.

Protein Name

Stromelysin-2 (SL-2)

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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