Anti-Macrophage Inflammatory Protein 1 beta/CCL4 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Chemokine (C-C motif) ligand 4, also known as CCL4, is a protein which in humans is encoded by the CCL4 gene. It is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. CCL4 is a major HIV-suppressive factor produced by CD8+ T cells. Performing-low memory CD8+ T cells that normally synthesize MIP-1-beta. Modi et al. (1991) assigned the SCYA4 gene to a slightly more distal location than had Irving et al. (1990) : 17q21-q23 rather than 17q11-q21.
Synonyms
C-C motif chemokine 4; Immune activation protein 2; ACT-2; ACT2; Macrophage inflammatory protein 1-beta; MIP-1-beta; Protein H400; SIS-gamma; Small-inducible cytokine A4; Ccl4; Mip1b, Scya4
Gene Name
CCL4
Gene ID
20303
UniProt
P14097
Host
Rabbit
Reactivity
Mouse
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of mouse CCL4.
Clonality
Polyclonal
Tissue Specificity
Ubiquitous. Isoform Mdm2-A, isoform Mdm2-B, isoform Mdm2-C, isoform Mdm2-D, isoform Mdm2-E, isoform Mdm2-F and isoform Mdm2-G are observed in a range of cancers but absent in normal tissues.
Applications
Flow Cytometry
Field of Research
Antiviral Signaling, Chemokines, Immune System Diseases, Immunology, Innate Immunity, Macrophage/Inflammation
Purification
Immunogen affinity purified.
Form
Liquid
Function
Monokine with inflammatory and chemokinetic properties.
References & Citations
1. Irving SG, Zipfel PF, Balke J, McBride OW, Morton CC, Burd PR, Siebenlist U, Kelly K (June 1990) . Nucleic Acids Res. 18 (11) : 3261–70. 2. Bystry RS, Aluvihare V, Welch KA, Kallikourdis M, Betz AG (December 2001) . B cells and professional APCs recruit regulatory T cells via CCL4. Nat. Immunol. 2 (12) : 1126–32. 3. Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P (December 1995) . Science (journal) 270 (5243) : 1811–5. 4. Kamin-Lewis R, Abdelwahab SF, Trang C, Baker A, DeVico AL, Gallo RC, Lewis GK (July 2001) .
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
10168 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
C-C motif chemokine 4
Subcellular Location
Secreted.
Sequence Similarities
Belongs to the MDM2/MDM4 family.
Protein Name
C-C motif chemokine 4
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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