Anti-Insulin-like growth factor I IGF1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Insulin-like growth factor 1 (IGF-1) also known as somatomedin C or mechano growth factor is a protein that in humans is encoded by the IGF1 gene. IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is used for the treatment of growth failure. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7649 daltons.Justice et al. (1990) placed the mouse IGF1 gene on chromosome 10.

Synonyms

Insulin-like growth factor I; IGF-I; Mechano growth factor; MGF; Somatomedin-C; IGF1; IBP1

Gene Name

IGF1

Gene ID

3479

UniProt

P05019

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human IGF-1, different from the mouse and rat sequences by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Detected in brain cortex (at protein level) . Detected in blood platelets. .

Applications

Flow Cytometry

Field of Research

Cancer, Developmental Biology, Growth Factors, Growth Factors/Hormones, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. .

References & Citations

1. Höppener JW, de Pagter-Holthuizen P, Geurts van Kessel AH, Jansen M, Kittur SD, Antonarakis SE, Lips CJ, Sussenbach JS (1985) . The human gene encoding insulin-like growth factor I is located on chromosome 12. Hum. Genet. 69 (2) : 157–60. 2. Jansen M, van Schaik FM, Ricker AT, Bullock B, Woods DE, Gabbay KH, Nussbaum AL, Sussenbach JS, Van den Brande JL (1983) . Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature 306 (5943) : 609–11.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

21841 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Insulin-like growth factor I

Subcellular Location

Secreted.

Sequence Similarities

Belongs to the insulin family.

Protein Name

Insulin-like growth factor I (IGF-I)

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

More Discoveries

Explore Other Products

Browse additional items from our catalog

GTR15321801 1 Vial

Lentiviral human SRGN shRNA (UAS) - Lentiviral human SRGN shRNA (UAS) (100)

View Details

214735-Biotin 100 µL

CD8 (Biotin)

View Details

31811 each

Kylt® H5/H7/H9 LD 25

View Details

034120-ML405 100 µL

COPS7A, CT (COPS7A, CSN7A, DERP10, COP9 signalosome complex subunit 7a, Dermal papilla-derived protein 10, JAB1-containing signalosome subunit 7a) (MaxLight 405) discontinued

View Details

282886-01 1 mg

Midazolam 2-oxide discontinued

View Details

282886-02 2 mg

Midazolam 2-oxide discontinued

View Details

Anti-Insulin-like growth factor I IGF1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Synonyms

Gene Name

Gene ID

UniProt

Host

Reactivity

Cross Reactivity

Immunogen

Clonality

Tissue Specificity

Applications

Field of Research

Purification

Form

Function

References & Citations

Storage Conditions

Calculated Molecular Weight

Specificity

Applications Notes

Gene Name Synonym

Subcellular Location

Sequence Similarities

Protein Name

Isotype

Contents

Explore Other Products

Lentiviral human SRGN shRNA (UAS) - Lentiviral human SRGN shRNA (UAS) (100)

CD8 (Biotin)

Kylt® H5/H7/H9 LD 25

COPS7A, CT (COPS7A, CSN7A, DERP10, COP9 signalosome complex subunit 7a, Dermal papilla-derived protein 10, JAB1-containing signalosome subunit 7a) (MaxLight 405) discontinued

Midazolam 2-oxide discontinued

Midazolam 2-oxide discontinued