Indole-3-carbinol
Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1) .
Product Specifications
CAS Number
700-06-1
Product Name Alternative
Indole-3-methanol
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Aryl Hydrocarbon Receptor; E1/E2/E3 Enzyme; Endogenous Metabolite; NF-κB
Type
Natural Products
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Indole-3-carbinol.html
Purity
99.16
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OCC1=CNC2=C1C=CC=C2
Molecular Formula
C9H9NO
Molecular Weight
147.18
Precautions
H315, H319
References & Citations
[1]Mohammadi S, et al. Indole-3-carbinol induces G1 cell cycle arrest and apoptosis through aryl hydrocarbon receptor in THP-1 monocytic cell line.J Recept Signal Transduct Res. 2017 Oct;37 (5) :506-514.|[2]Safa M, et al. Indole-3-carbinol suppresses NF-κB activity and stimulates the p53 pathway in pre-B acute lymphoblastic leukemia cells. Tumour Biol. 2015 May;36 (5) :3919-30.|[3]Lee YR, et al. Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science. 2019 May 17;364 (6441) . pii: eaau0159.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
Phase 2
Isoform
Human Endogenous Metabolite; NF-κB
Available Sizes
Frequently Asked Questions
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