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Anti-Connexin 40/GJA5 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Connexin proteins oligomerize to form intercellular channels, called gap junctions, through which ions and small molecules move between adjacent cells. Connexin 40 (Gap junction alpha-5 protein) is a protein that in humans is encoded by the GJA5 gene.This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described.

Synonyms

Gap junction alpha-5 protein; Connexin-40; Cx40; GJA5

Gene Name

GJA5

Gene ID

2702

UniProt

P36382

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Connexin 40/GJA5, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Cardiovascular, Cell Adhesion, Cytoskeleton/ECM, Signal Transduction, Vasculature

Purification

Immunogen affinity purified.

Form

Liquid

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

References & Citations

1. Entrez Gene: GJA5 gap junction protein, alpha 5, 40kDa

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

40380 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Gap junction alpha-5 protein

Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Sequence Similarities

Belongs to the connexin family. Beta-type (group I) subfamily.

Protein Name

Gap junction alpha-5 protein

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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