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Anti-TNF beta/LTA Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

Lymphotoxin (previously known as tumor necrosis factor-beta) is a lymphokine cytokine. It is a protein that is produced by Th1 type T-cells and induces vascular endothelial cells to change their surface adhesion molecules to allow phagocytic cells to bind to them. Lymphotoxin is homologous to Tumor Necrosis Factor beta, but secreted by T-cells. It is paracrine due to the small amounts produced. The effects are similar to TNF-alpha, but TNF-beta is also important for the development of lymphoid organs. Nedwin et al. (1985) found that TNFA and TNFB are closely linked on chromosome 6. Study of hybrid cells made with rearranged human chromosome 6 showed that both TNFA and TNFB map to the 6p23-q12 segment.

Synonyms

Lymphotoxin-alpha; LT-alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1; LTA; TNFB, TNFSF1

Gene Name

LTA

Gene ID

4049

UniProt

P01374

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human TNF beta, different from the related mouse sequence by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. .

Applications

Flow Cytometry

Field of Research

Biochemicals, Chemical Type, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipid Signaling, Metabolic Signaling Pathways, Metabolism, Pathways and Processes

Purification

Immunogen affinity purified.

Form

Liquid

Function

Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.

References & Citations

1. Parham, Peter (2005) . Chapter 6: T-cell mediated immunity. The immune system (2nd ed.) . New York: Garland Science. p. 172.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

22297 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Lymphotoxin-alpha

Subcellular Location

Secreted. Membrane. The homotrimer is secreted. The heterotrimer is membrane-associated.

Sequence Similarities

Belongs to the tumor necrosis factor family.

Protein Name

Lymphotoxin-alpha (LT-alpha)

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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