What sizes are available for Anti-Presenilin 2/PSEN2 Antibody Picoband® Fluoro647 Conjugated?

Anti-Presenilin 2/PSEN2 Antibody Picoband® Fluoro647 Conjugated is available in the following size(s): 100 µg/Vial.

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.

Do you provide a Certificate of Analysis (CoA) for this product?

A Certificate of Analysis is available for most products upon request. Contact our support team with the lot number to obtain the relevant CoA.

Is this product suitable for live cell imaging?

Suitability for live cell imaging depends on the specific reagent and conjugate used. Check the datasheet for imaging-specific validation, or contact us for guidance.

Anti-Presenilin 2/PSEN2 Antibody Picoband® Fluoro647 Conjugated

Q: What is the catalog number for Anti-Presenilin 2/PSEN2 Antibody Picoband® Fluoro647 Conjugated?

The catalog number for Anti-Presenilin 2/PSEN2 Antibody Picoband® Fluoro647 Conjugated is PA1358-Fluoro647.

Selected Variant

PA1358-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Presenilin-2 is a protein that in humans is encoded by the PSEN2 gene. Kovacs et al. (1996) demonstrated that the expression patterns of PS1 and PS2 in the brain are extremely similar to each other and that messages for both are primarily detectable in neuronal populations. Immunochemical analyses indicated that PS1 and PS2 are similar in size and localize to similar intracellular compartments (endoplasmic reticulum and Golgi complex) . Li et al. (1997) demonstrated that wildtype PS1 and PS2 are localized to the nuclear membrane, its associated interphase kinetochores, and the centrosomes.In melanocytic cells PSEN2 gene expression may be regulated by MITF.

Synonyms

Presenilin-2; PS-2;3.4.23.-; AD3LP; AD5; E5-1; STM-2; Presenilin-2 NTF subunit; Presenilin-2 CTF subunit; PSEN2; AD4, PS2, PSNL2, STM2

Gene Name

PSEN2

Gene ID

5664

UniProt

P49810

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Presenilin 2, different from the related mouse and rat sequences by two amino acids.

Clonality

Polyclonal

Tissue Specificity

Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney. .

Applications

Flow Cytometry

Field of Research

Alzheimer's Disease, Cancer, Cancer Metabolism, Metabolism, Metabolism Processes, Neurodegenerative Disease, Neurology Process, Neuroscience, Pathways and Processes, Response To Hypoxia

Purification

Immunogen affinity purified.

Form

Liquid

Function

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein) . Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. .

References & Citations

1. Levy-Lahad E, Wijsman EM, Nemens E, Anderson L, Goddard KA, Weber JL, Bird TD, Schellenberg GD (September 1995) . A familial Alzheimer's disease locus on chromosome 1. 2. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008) . Novel MITF targets identified using a two-step DNA microarray strategy.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

50140 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Presenilin-2

Subcellular Location

Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein .

Sequence Similarities

Belongs to the peptidase A22A family.

Protein Name

Presenilin-2 (PS-2)

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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