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Anti-SFTPA1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Surfactant protein A is an innate immune system collectin. The gene encoding SP-A map to mouse chromosome 14.1. Surfactant protein-A, which plays a role in innate host defense in the lung, is also expressed in the Eustachian tube. We report that the frequency of specific surfactant protein-A haplotypes and genotypes differs between children with recurrent otitis media compared with a control population.

Synonyms

Pulmonary surfactant-associated protein A1; PSP-A; PSPA; SP-A; SP-A1;35 kDa pulmonary surfactant-associated protein; Alveolar proteinosis protein; Collectin-4; SFTPA1; COLEC4, PSAP, SFTP1, SFTPA, SFTPA1B

Gene Name

SFTPA1

Gene ID

653509

UniProt

Q8IWL2

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human SFTPA1, different from the rat sequence by two amino acids.

Clonality

Polyclonal

Tissue Specificity

Expressed in neurons of the rolandic area of the brain (at protein level) . Expressed in the brain.

Applications

Flow Cytometry

Field of Research

Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.

References & Citations

1. Moore, K. J., D'Amore-Bruno, M. A., Korfhagen, T. R., Glasser, S. W., Whitsett, J. A., Jenkins, N. A., Copeland, N. G. Chromosomal localization of three pulmonary surfactant protein genes in the mouse. Genomics 12: 388-393, 1992. 2. Ramet, M., Lofgren, J., Albo, O.-P., Hallman, M. Surfactant protein-A gene locus associated with recurrent otitis media. J. Pediat. 138: 266-268, 2001.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

26242 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Pulmonary surfactant-associated protein A1

Subcellular Location

Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.

Sequence Similarities

Belongs to the SFTPA family.

Protein Name

Pulmonary surfactant-associated protein A1 (PSP-A/PSPA/SP-A/SP-A1)

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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