Anti-N-Cadherin-2 CDH2 CD325-Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
N-cadherin (NCAD) is a member of the cadherin cell-cell adhesion receptor family that includes P-, E-, and R-cadherin and liver cell adhesion molecule (L-CAM) . N-Cadherin, , also known as Cadherin-2, encodes a 907-amino acid protein that includes a 159-amino acid signal sequence. Human and mouse nucleotide sequences are 96% identical. Mouse Ncad gene consists of 16 exons dispersed over more than 200 kb of genomic DNA. Human N-cadherin gene contains 16 exons and its sequence is highly similar to both the mouse NCAD gene (including the large first and second introns) and other cadherin genes. N-cadherin is mapped to 18q11.2. Cadherin regulates dendritic spine morphogenesis.
Synonyms
Cadherin-2; CDw325; Neural cadherin; N-cadherin; CD325; CDH2; CDHN, NCAD
Gene Name
CDH2
Gene ID
1000
UniProt
P19022
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human N Cadherin, identical to the related rat and mouse sequences.
Clonality
Polyclonal
Applications
Flow Cytometry
Field of Research
Cadherins, Cell Adhesion, Cytoskeleton/ECM, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity) . .
References & Citations
1. Miyatani, S.; Copeland, N. G.; Gilbert, D. J.; Jenkins, N. A.; Takeichi, M. : Genomic structure and chromosomal mapping of the mouse N-cadherin gene. Proc. Nat. Acad. Sci. 89: 8443-8447, 1992. 2. Walsh, F. S.; Barton, C. H.; Putt, W.; Moore, S. E.; Kelsell, D.; Spurr, N.; Goodfellow, P. N. : N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene. J. Neurochem. 55: 805-812, 1990. 3. Togashi, H.; Abe, K.; Mizoguchi, A.; Takaoka, K.; Chisaka, O.; Takeichi, M. : Cadherin regulates dendritic spine morphogenesis. Neuron 35: 77-89, 2002.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
100 kDa
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Cadherin-2
Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Name
Cadherin-2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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