Anti-Metalloproteinase inhibitor 4 TIMP4 Antibody Picoband® Fluoro488 Conjugated
Selected Variant
PA1078-Fluoro488
Size: 100 µg/Vial
Product Specifications
Background
Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene. And this gene is mapped to chromosome 3p25. This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling.
Synonyms
Metalloproteinase inhibitor 4; Tissue inhibitor of metalloproteinases 4; TIMP-4; TIMP4
Gene Name
TIMP4
Gene ID
7079
UniProt
Q99727
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human TIMP4, different from the related rat sequence by two amino acids, and from the related mouse sequence by three amino acids.
Clonality
Polyclonal
Tissue Specificity
Abundant in heart and present at low levels in many other tissues.
Applications
Flow Cytometry
Field of Research
Angiogenesis, Cancer, Cardiovascular, Cell Biology, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Protease Inhibitors, Proteolysis/Ubiquitin
Purification
Immunogen affinity purified.
Form
Liquid
Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP- 9.
References & Citations
1. Entrez Gene: THPO TIMP4 (myeloproliferative leukemia virus oncogene ligand, megakaryocyte growth and development factor) . 2. Olson TM, Hirohata S, Ye J, Leco K, Seldin MF, Apte SS (Sep 1998) . Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively. Genomics. 51 (1) : 148–151.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
25503 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Metalloproteinase inhibitor 4
Subcellular Location
Secreted.
Sequence Similarities
Belongs to the protease inhibitor I35 (TIMP) family.
Protein Name
Metalloproteinase inhibitor 4
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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