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Anti-Sonic Hedgehog/SHH Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

The mouse, chicken, and zebrafish Shh homologs are highly conserved. SHH expression was not detected in adult tissues examined. However, it was expressed in fetal intestine, liver, lung, and kidney. SHH gene is mapped to 7q. SHH mutations are not a frequent cause of isolated oral clefts.

Synonyms

Sonic hedgehog protein; SHH; HHG-1; Sonic hedgehog protein N-product; Sonic hedgehog protein C-product; SHH

Gene Name

SHH

Gene ID

6469

UniProt

Q15465

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Sonic Hedgehog, identical to the related rat and mouse sequences.

Clonality

Polyclonal

Tissue Specificity

Expressed in fetal intestine, liver, lung, and kidney. Not expressed in adult tissues.

Applications

Flow Cytometry

Field of Research

Developmental Families, Domain Families, Embryogenesis, Embryonic Stem Cells, Epigenetics and Nuclear Signaling, Hypoxia, Intracellular, Metabolism, Metabolism Processes, Neural Stem Cells, Oncoproteins/Suppressors, Organogenesis, Pathways and Processes, Response To Hypoxia, Secreted, Signaling Pathways, Stem Cells, Surface Molecules, Transcription, Tumor Suppressors

Purification

Immunogen affinity purified.

Form

Liquid

Function

Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior- posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO (By similarity) . .

References & Citations

1. Tsukurov, O.; Boehmer, A.; Flynn, J.; Nicolai, J.-P.; Hamel, B. C. J.; Traill, S.; Zaleske, D.; Mankin, H. J.; Yeon, H.; Ho, C.; Tabin, C.; Seidman, J. G.; Seidman, C. : A complex bilateral polysyndactyly disease locus maps to chromosome 7q36. Nature Genet. 6: 282-286, 1994.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

49607 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Sonic hedgehog protein

Subcellular Location

Sonic hedgehog protein C-product: Secreted, extracellular space . The C-terminal peptide diffuses from the cell. .

Sequence Similarities

Belongs to the hedgehog family.

Protein Name

Sonic hedgehog protein

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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