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Anti-Fibroblast growth factor 4 FGF4 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Fibroblast growth factor 4 (FGF4), also known as Heparin Secretary Transforming (HSTF1) . HST1, for which the designation HSTF1 was proposed for human gene nomenclature, is a heparin-binding growth factor with significant homology to human fibroblast growth factors and the mouse Int-2 protein. By in situ hybridization, Adelaide et al. (1988) mapped the HST gene to chromosome 11q13. The HST1 protein is a heparin-binding growth factor with significant homology with human fibroblast growth factors and the mouse Int-2 protein.

Synonyms

Fibroblast growth factor 4; FGF-4; Heparin secretory-transforming protein 1; HST; HST-1; HSTF-1; Heparin-binding growth factor 4; HBGF-4; Transforming protein KS3; FGF4; HST, HSTF1, KS3

Gene Name

FGF4

Gene ID

2249

UniProt

P08620

Host

Rabbit

Reactivity

Rat, Mouse, Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human FGF4, identical to the related rat and mouse sequences.

Clonality

Polyclonal

Tissue Specificity

Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication (at protein level) . Isoform 2 degradation coincides with the cessation of nuclear DNA replication (at protein level) . .

Applications

Flow Cytometry

Field of Research

Cancer, Cardiovascular, Growth Factors, Growth Factors/Hormones, Oncoproteins, Oncoproteins/Suppressors, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. .

References & Citations

1. Huebner, K.; Ferrari, A. C.; Delli Bovi, P.; Croce, C. M.; Basilico, C. : The FGF-related oncogene, K-FGF, maps to human chromosome region 11q13, possibly near int-2. Oncogene Res. 3: 263-270, 1988. 2. Adelaide, J.; Mattei, M.-G.; Marics, I.; Raybaud, F.; Planche, J.; De Lapeyriere, O.; Birnbaum, D. : Chromosomal localization of the hst oncogene and its co-amplification with the int.2 oncogene in a human melanoma. Oncogene 2: 413-416, 1988. 3. Yoshida, T.; Tsutsumi, M.; Sakamoto, H.; Miyagawa, K.; Teshima, S.; Sugimura, T.; Terada, M. : Expression of the HST1 oncogene in human germ cell tumors. Biochem. Biophys. Res. Commun. 155: 1324-1329, 1988.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

22048 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Fibroblast growth factor 4

Subcellular Location

Secreted .

Sequence Similarities

Belongs to the dUTPase family.

Protein Name

Fibroblast growth factor 4 (FGF-4)

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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