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Anti-CXCR2 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

CXCR2 is a receptor for Interleukin 8, which is a powerful neutrophil chemotactic factor. It is a member of the GPCR family (subfamily, chemokine) . Binding of IL8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL8 with a high affinity and to GRO/MGSA and NAP2 also with a high affinity. It has been reported to be expressed in a wide variety of tissues. ESTs have been isolated from human placenta and thymus libraries.

Synonyms

C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; CDw128b; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; IL-8 receptor type 2; CD182; CXCR2; IL8RB

Gene Name

CXCR2

Gene ID

3579

UniProt

P25025

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human CXCR2, different from the related mouse sequence by six amino acids.

Clonality

Polyclonal

Tissue Specificity

Found in plasma.

Applications

Flow Cytometry

Field of Research

Cell Biology, Cell Cycle, Cell Division, G Protein Signaling, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Form

Liquid

Function

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

References & Citations

1. Murphy P.M., Tiffany H.L.; Cloning of complementary DNA encoding a functional human interleukin-8 receptor.; Science 253:1280-1283 (1991) . 2. Cerretti D.P., Kozlosky C.J., Vanden Bos T., Nelson N., Gearing D.P., Beckmann M.P.; Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2.; Mol. Immunol. 30:359-367 (1993) . 3. Sprenger H., Lloyd A.R., Lautens L.L., Bonner T.I., Kelvin D.J.; Structure, genomic organization, and expression of the human interleukin-8 receptor B gene.; J. Biol. Chem. 269:11065-11072 (1994) .

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

40759 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

C-X-C chemokine receptor type 2

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Protein Name

C-X-C chemokine receptor type 2 (CXC-R2/CXCR-2)

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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