Anti-C Reactive Protein/CRP Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
C Reactive Protein (CRP) is a major acute phase reactant synthesized primarily in the liver hepatocytes. It is composed of 5 identical, 21,500-molecular weight subunits. CRP mediates activities associated with preimmune nonspecific host resistance. CRP shows the strongest association with cardiovascular events. It is detectable on the surface of about 4% of normal peripheral blood lymphocytes. Acute phase reactant CRP is produced in the liver.
Synonyms
C-reactive protein; C-reactive protein (1-205) ; CRP; PTX1
Gene Name
CRP
Gene ID
1401
UniProt
P02741
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human C Reactive Protein.
Clonality
Polyclonal
Tissue Specificity
Found in plasma.
Applications
Flow Cytometry
Field of Research
Apoptosis, Atherosclerosis, Cardiovascular, Chromatin Binding Proteins, Complement, DNA/RNA Binding, Epigenetics and Nuclear Signaling, Immunology, Innate Immunity, Macrophage/Inflammation, Metabolism, Vascular Inflammation
Purification
Immunogen affinity purified.
Form
Liquid
Function
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
References & Citations
1. Kilpatrick, J. M.; Volanakis, J. E. : Molecular genetics, structure, and function of C-reactive protein. Immun. Res. 10: 43-53, 1991. 2. Kuta, A. E.; Baum, L. L. : C-reactive protein is produced by a small number of normal human peripheral blood lymphocytes. J. Exp. Med. 164: 321-326, 1986. 3. Oliveira, E. B.; Gotshlich, E. C.; Liu, T. : Primary structure of human C-reactive protein. J. Biol. Chem. 254: 489-502, 1979.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
25039 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
C-reactive protein
Subcellular Location
Secreted.
Sequence Similarities
Belongs to the pentaxin family.
Protein Name
C-reactive protein
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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