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Anti-C-C chemokine receptor type 5 CCR5 Antibody Picoband® Fluoro647 Conjugated

Q: What is the catalog number for Anti-C-C chemokine receptor type 5 CCR5 Antibody Picoband® Fluoro647 Conjugated?

The catalog number for Anti-C-C chemokine receptor type 5 CCR5 Antibody Picoband® Fluoro647 Conjugated is PA1016-Fluoro647.

Selected Variant

PA1016-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Human CC chemokine receptor 5 (CCR5), which is 17.5 kb from the CMKBR2 gene, encodes a 352-amino acid protein with a calculated molecular mass of 40,600 Da. It is organized into four exons and two introns. Human CCR5 is a co-receptor for macrophage-tropic strains of human immunodeficiency virus (HIV) -1 and is expressed by bone-marrow-derived cells. CCR5 is expressed on neurons, astrocytes, and microglia in the central nervous system, and on epithelium, endothelium, vascular smooth muscle and fibroblasts in other tissues. Functionally, CCR5 mediates the activation of cells by the chemokines macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, and RANTES, and serves as a fusion cofactor for macrophage-tropic strains of human immunodeficiency virus type 1.

Synonyms

C-C chemokine receptor type 5; C-C CKR-5; CC-CKR-5; CCR-5; CCR5; CHEMR13; HIV-1 fusion coreceptor; CD195; CCR5; CMKBR5

Gene Name

CCR5

Gene ID

1234

UniProt

P51681

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human CCR5, different from the related rat sequence by two amino acids.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung. .

Applications

Flow Cytometry

Field of Research

Alzheimer's Disease, Antiviral Signaling, Atherosclerosis, Cancer, Cardiovascular, Chemokines, G Protein Signaling, Host-Virus Interaction, Immune System Diseases, Immunology, Innate Immunity, Interspecies Interaction, Macrophage/Inflammation, Microbiology, Neurodegenerative Disease, Neurology Process, Neuroscience, Signal Transduction, Signaling Pathway, Vascular Inflammation

Purification

Immunogen affinity purified.

Form

Liquid

Function

Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates. .

References & Citations

1. Samson M, Labbe O, Mollereau C, Vassart G, Parmentier M. Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry. 1996 Mar 19; 35 (11) :3362-7. 2. Rottman JB, Ganley KP, Williams K, Wu L, Mackay CR, Ringler DJ. Cellular localization of the chemokine receptor CCR5. Correlation to cellular targets of HIV-1 infection. Am J Pathol. 1997 Nov; 151 (5) :1341-51. 3. Mummidi S, Ahuja SS, McDaniel BL, Ahuja SK. The human CC chemokine receptor 5 (CCR5) gene. Multiple transcripts with 5'-end heterogeneity, dual promoter usage, and evidence for polymorphisms within the regulatory regions and noncoding exons. J Biol Chem. 1997 Dec 5; 272 (49) :30662-71.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

40524 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

C-C chemokine receptor type 5

Subcellular Location

Cell membrane ; Multi-pass membrane protein .

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Protein Name

C-C chemokine receptor type 5 (C-C CKR-5/CC-CKR-5/CCR-5/CCR5)

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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