Anti-Alkaline Phosphatase/ALPL Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Alkaline phosphatase, tissue-nonspecific isozyme is an enzyme that in humans is encoded by the ALPL gene. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific) . The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. Liver/bone/kidney alkaline phosphatase, also known as tissue-nonspecific alkaline phosphatase, acts physiologically as a lipid-anchored phosphoethanolamine (PEA) and pyridoxal-5-prime-phosphate (PLP) ectophosphatase Mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked ly to a disorder known as hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects.

Synonyms

Alkaline phosphatase, tissue-nonspecific isozyme; AP-TNAP; TNSALP;3.1.3.1; Alkaline phosphatase liver/bone/kidney isozyme; Alpl

Gene Name

ALPL

Gene ID

P08289

UniProt

P08289

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of rat Alkaline Phosphatase, different from the related mouse sequence by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Widely expressed, with highest expression in brain. .

Applications

Flow Cytometry

Field of Research

Cancer, Cell Biology, Cell Cycle, Kinases/Phosphatases, Tags & Cell Markers, Tumor Biomarkers

Purification

Immunogen affinity purified.

Form

Liquid

Function

This isozyme may play a role in skeletal mineralization.

References & Citations

1. Weiss MJ, Henthorn PS, Lafferty MA, Slaughter C, Raducha M, Harris H (Oct 1986) . Isolation and characterization of a cDNA encoding a human liver/bone/kidney-type alkaline phosphatase. Proc Natl Acad Sci U S A 83 (19) : 7182–6. 2. Swallow DM, Povey S, Parkar M, Andrews PW, Harris H, Pym B, Goodfellow P (May 1988) . Mapping of the gene coding for the human liver/bone/kidney isozyme of alkaline phosphatase to chromosome 1. Ann Hum Genet 50 (Pt 3) : 229–35. 3. Entrez Gene: ALPL alkaline phosphatase, liver/bone/kidney 4. Fedde, K. N., Whyte, M. P. Alkaline phosphatase (tissue-nonspecific isoenzyme) is a phosphoethanolamine and pyridoxal-5-prime-phosphate ectophosphatase: normal and hypophosphatasia fibroblast study. Am. J. Hum. Genet. 47: 767-775, 1990.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

57659 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Alkaline phosphatase, tissue-nonspecific isozyme

Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor.

Sequence Similarities

Contains 12 fibronectin type-I domains.

Protein Name

Alkaline phosphatase, tissue-nonspecific isozyme

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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Anti-Alkaline Phosphatase/ALPL Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Synonyms

Gene Name

Gene ID

UniProt

Host

Reactivity

Cross Reactivity

Immunogen

Clonality

Tissue Specificity

Applications

Field of Research

Purification

Form

Function

References & Citations

Storage Conditions

Calculated Molecular Weight

Specificity

Applications Notes

Gene Name Synonym

Subcellular Location

Sequence Similarities

Protein Name

Isotype

Contents

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