Anti-Growth Hormone/GH1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Growth Hormone (GH) is mapped to 17q22-q24. Growth hormone (GH) is synthesized by acidophilic or somatotropic cells of the anterior pituitary gland. Human growth hormone has a molecular mass of 22,005 and contains 191 amino acid residues with 2 disulfide bridges. It binds two receptor molecules and thereby induces signal transduction through receptor dimerization. At high concentrations, GH acts as an antagonist because of a large difference in affinities at the respective binding sites.
Synonyms
Somatotropin; Growth hormone; GH; GH-N; Growth hormone 1; Pituitary growth hormone; GH1
Gene Name
GH1
Gene ID
2688
UniProt
P01241
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E. coli-derived human GH recombinant protein (Position: F27-F217) .
Clonality
Polyclonal
Applications
Flow Cytometry
Field of Research
Developmental Biology, Growth Factors/Hormones, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
References & Citations
1. Niall, H. D.; Hogan, M. L.; Sauer, R.; Rosenblum, I. Y.; Greenwood, F. C. : Sequence of pituitary and placental lactogenic and growth hormones: evolution from a primordial peptide by gene reduplication. Proc. Nat. Acad. Sci. 68: 866-869, 1971. 2. Sundstrom, M.; Lundqvist, T.; Rodin, J.; Giebel, L. B.; Milligan, D.; Norstedt, G. : Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 angstrom resolution. J. Biol. Chem. 271: 32197-32203, 1996.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
24847 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Somatotropin
Subcellular Location
Secreted.
Sequence Similarities
Belongs to the somatotropin/prolactin family.
Protein Name
Somatotropin
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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