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Anti-Interleukin-7 IL7 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

IL-7, Interleukin 7, is a protein that in humans is encoded by the IL-7 gene. IL-7 a hematopoietic growth factor secreted by stromal cells in the red marrow and thymus. It is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells but is not produced by lymphocytes. By the combination of approaches, IL-7 is located on 8q12-q13. IL-7 is critical for early T-cell development and homeostasis of naive and memory CD8-positive T cells. It signals through the IL-7 receptor complex, which consists of the IL7R-alpha chain and the common IL2R-gamma chain is critical for early T-cell development and homeostasis of naive and memory CD8 -positive T cells. It signals through the IL-7 receptor complex, which consists of the IL7R-alpha chain and the common IL2R-gamma chain.

Synonyms

Interleukin-7; IL-7; IL7

Gene Name

IL7

Gene ID

3574

UniProt

P13232

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E. coli-derived human IL-7 recombinant protein (Position: D26-H177) .

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Cytokines, Immunology, Innate Immunity, Interleukins

Purification

Immunogen affinity purified.

Form

Liquid

Function

Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

References & Citations

1. Goodwin RG, Lupton S, Schmierer A, Hjerrild KJ, Jerzy R, Clevenger W, Gillis S, Cosman D, Namen AE (January 1989) . Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells. Proc. Natl. Acad. Sci. U.S.A. 86 (1) : 302–6. 2. Lupton SD, Gimpel S, Jerzy R, et al. (1990) . Characterization of the human and murine IL-7 genes. J. Immunol. 144 (9) : 3592–601. 3. Sutherland GR, Baker E, Fernandez KE, Callen DF, Goodwin RG, Lupton S, Namen AE, Shannon MF, Vadas MA (July 1989) . The gene for human interleukin 7 (IL7) is at 8q12-13. Hum. Genet. 82 (4) : 371–2.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

20187 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Interleukin-7

Subcellular Location

Secreted.

Sequence Similarities

Belongs to the IL-7/IL-9 family.

Protein Name

Interleukin-7 (IL-7)

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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