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Anti-Tropomyosin (36/39 kDa) Tpm1 Antibody (Monoclonal, TM31)

Selected Variant

MA1095

Size: 100 µg/Vial

Boster Bio Anti-Tropomyosin (36/39 kDa) Tpm1 Antibody (Monoclonal, TM31) catalog # MA1095. Tested in WB applications. This antibody reacts with Chicken, Human, Mouse, Rat.

Product Specifications

Background

The tropomyosins are a family of actin filament binding proteins. These proteins were first isolated from skeletal muscle, but later identified in many nonmuscle tissues. Tropomyosins are ubiquitous proteins of 35 to 45 kD associated with the actin filaments of myofibrils and stress fibers. Vertebrates have at least 4 different tropomyosin genes; in humans, they are named TPM1, TPM2, TPM3, and TPM4. Tropomyosins expressed as different isoforms in muscle and non-muscle cells.

Synonyms

Tropomyosin alpha-1 chain; Alpha-tropomyosin; Tropomyosin-1; Tpm1; Alpha-tm, Tpma

Gene Name

TPM1

Gene ID

Human (7168), Mouse (22003), Rat (24851)

UniProt

P04692

Host

Mouse

Reactivity

Chicken, Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

Chicken gizzard tropomyosin.

Clonality

Monoclonal

Clone

Clone: TM31

Tissue Specificity

TPM1: Detected in primary breast cancer tissues butundetectable in normal breast tissues in Sudanese patients.Isoform 1 is expressed in adult and fetal skeletal muscle andcardiac tissues, with higher expression levels in the cardiactissues. Isoform 10 is expressed in adult and fetal cardiactissues, but not in skeletal muscle.

Applications

WB

Field of Research

Actin, etc., Cardiovascular, Cytoskeleton, Cytoskeleton/ECM, Hypertrophy, Microfilaments, Signal Transduction

Purification

Ascites

Concentration

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Form

Lyophilized

Reconstitution

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Function

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

References & Citations

1. Lees-Miller, J. P.; Helfman, D. M. : The molecular basis for tropomyosin isoform diversity. BioEssays 13: 429-437, 1991. 2. Gariboldi, M.; Manenti, G.; Dragani, T. A.; Pierotti, M. A. : Chromosome mapping of nine tropomyosin-related sequences in mice. Mammalian Genome 6: 273-277, 1995.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

32681 MW

Observed Molecular Weight

35-45 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Tropomyosin alpha-1 chain

Subcellular Location

Cytoplasm, cytoskeleton.

Sequence Similarities

Belongs to the tenascin family.

Protein Name

Tropomyosin alpha-1 chain

Isotype

Mouse IgG1

Contents

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.

Price

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