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Anti-Insulin Ins2 Antibody (Monoclonal, K36AC10)

Selected Variant

MA1052

Size: 100 µg/Vial

Boster Bio Anti-Insulin Ins2 Antibody (Monoclonal, K36AC10) catalog # MA1052. Tested in IHC applications. This antibody reacts with Human, Rabbit, Rat.

Product Specifications

Background

Insulin, synthesized by the beta cells of the islets of Langerhans, consists of 2 dissimilar polypeptide chains, A and B, which are linked by 2 disulfide bonds. The insulin gene contains 3 exons and 2 introns; exon 2 encodes the signal peptide, the B chain, and part of the C peptide, while exon 3 encodes the remainder of the C peptide and the A chain. Localization of the human insulin gene to the distal end of the short arm of chromosome 11. Harper et al. (1981) and Harper and Saunders (1981) assigned the insulin gene to 11p15.5 by in situ hybridization.

Synonyms

Insulin-2; Insulin-2 B chain; Insulin-2 A chain; Ins2; Ins-2

Gene Name

INS

Gene ID

Human (3630), Mouse (16334), Rat (24509)

UniProt

P01323

Host

Mouse

Reactivity

Human, Rabbit, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

Human insulin.

Clonality

Monoclonal

Clone

Clone: K36AC10

Applications

IHC

Field of Research

Cancer, Chaperones, Heat Shock Proteins, Protein Trafficking, Signal Transduction, Tumor Biomarkers

Purification

Ascites

Concentration

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Form

Lyophilized

Reconstitution

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Function

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

References & Citations

1. Harper, M. E.; Ullrich, A.; Saunders, G. F. : Localization of the human insulin gene to the distal end of the short arm of chromosome 11. Proc. Nat. Acad. Sci. 78: 4458-4460, 1981. 2. Owerbach, D.; Bell, G. I.; Rutter, W. J.; Shows, T. B. : The insulin gene is located on chromosome 11 in human. Nature 286: 82-84, 1980. 3. Huerre, C.; Gilgenkrantz, S.; Leonard, C.; Pictet, R.; Kaplan, J. C.; Junien, C. : Regional assignment of the structural gene for insulin to 11p15.1-11p15.5 by deletion mapping. (Abstract) Cytogenet. Cell Genet. 37: 495, 1984.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

12339 MW

Observed Molecular Weight

70 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Insulin-2

Subcellular Location

Secreted.

Sequence Similarities

Belongs to the insulin family.

Protein Name

Insulin

Isotype

Mouse IgG1

Contents

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.

Price

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