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Anti-HSP70 Hspa1b Antibody (Monoclonal, BRM-22)

Boster Bio Anti-HSP70 Hspa1b Antibody (Monoclonal, BRM-22) catalog # MA1050. Tested in IHC, WB applications. This antibody reacts with Bovine, Human, Mouse, Rabbit, Rat.

Product Specifications

Background

Heat-shock proteins, or stress proteins, are expressed in response to heat shock and a variety of other stress stimuli including oxidative free radicals and toxic metal ions. Sargent et al. identified a duplicated HSP70 locus in the class III region of the major histocompatibility complex on 6p21.3. A duplicated locus encoding the major heat shock-induced protein HSP70 is located in the major histocompatibility complex (MHC) class III region 92 kilobases (kb) telomeric to the C2 gene. The 70-kd mammalian heat shock proteins are structurally and functionally related to the uncoating protein that releases clathrin triskelia from coated vesicles.

Synonyms

Heat shock 70 kDa protein 1B; Heat shock 70 kDa protein 1; HSP70.1; Hspa1b; Hcp70.1, Hsp70-1, Hsp70a1, Hspa1

Gene Name

HSPA1A; HSPA1B

Gene ID

Human (3303), Mouse (193740), Rat (24472), Human (3304), Mouse (15511), Rat (294254)

UniProt

P17879

Host

Mouse

Reactivity

Bovine, Human, Mouse, Rabbit, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

HSP70 isolated from bovine brain.

Clonality

Monoclonal

Clone

Clone: BRM-22

Tissue Specificity

Testis-specific.

Applications

IHC, WB

Field of Research

Cancer, Chaperones, Heat Shock Proteins, Protein Trafficking, Signal Transduction, Tumor Biomarkers

Purification

Ascites

Concentration

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Form

Lyophilized

Reconstitution

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Function

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation. .

References & Citations

1. Milner, C. M.; Campbell, R. D. : Structure and expression of the three MHC-linked HSP70 genes. Immunogenetics 32: 242-251, 1990. 2. Ungewickell, E. : The 70-kd mammalian heat shock proteins are structurally and functionally related to the uncoating protein that releases clathrin triskelia from coated vesicles. EMBO J. 4: 3385-3391, 1985.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

70176 MW

Observed Molecular Weight

70 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Heat shock 70 kDa protein 1B

Subcellular Location

Cytoplasm . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. .

Sequence Similarities

Belongs to the heat shock protein 70 family.

Protein Name

Heat shock 70 kDa protein 1A/1B

Isotype

Mouse IgG1

Contents

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.

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