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Anti-CEACAM5/Cd66e Monoclonal Antibody

Selected Variant

MA1023

Size: 100 µg/Vial

Boster Bio Anti-CEACAM5/Cd66e Monoclonal Antibody catalog # MA1023. Tested in IHC, WB applications. This antibody reacts with Human.

Product Specifications

Background

Carcinoembryonic antigen is a complex immunoreactive glycoprotein with a molecular weight of 180,000 comprising 60% carbohydrate. It is found in adenocarcinomas of endodermally derived digestive system epithelia and in fetal colon.Carcinoembryonic antigen is one of the most widely used tumor markers in serum immunoassay determinations of carcinoma.

Synonyms

Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen; CEA; Meconium antigen 100; CD66e; CEACAM5

Gene Name

CEACAM1

Gene ID

Human (1048), Mouse (73250)

UniProt

P06731

Host

Mouse

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

Carcinoembryonic antigen-related cell adhesion molecule 5 (CEA) isolated from a human colon adenocarcinoma cell line.

Clonality

Monoclonal

Clone

Clone: C6G9

Tissue Specificity

Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421) . Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.

Applications

IHC, WB

Field of Research

Cancer, Cell Type Markers, Human Protein, Microbiology, Oncoproteins/Suppressors, Protein, Tags & Cell Markers, Tumor Antigens, Tumor Associated, Tumor Biomarkers, Tumor Immunology, Tumor Suppressors, Tumor-Associated Antigens

Purification

Ascites

Concentration

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Form

Lyophilized

Reconstitution

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Function

Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933) . Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308) . Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells

References & Citations

1. Barnett, T.; Goebel, S. J.; Nothdurft, M. A.; Elting, J. J. : Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains. Genomics 3: 59-66, 1988. 2. Gold, P.; Freedman, S. O. : Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J. Exp. Med. 121: 439-462, 1965.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

37141 MW

Observed Molecular Weight

37 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Carcinoembryonic antigen-related cell adhesion molecule 5

Subcellular Location

Cell membrane

Sequence Similarities

Belongs to the immunoglobulin superfamily. CEA family.

Protein Name

Carcinoembryonic antigen-related cell adhesion molecule 5

Isotype

Mouse IgG1

Contents

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.

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