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Anti-Catenin Gamma (Plakoglobin) Jup Antibody (Monoclonal, 15F11)

Boster Bio Anti-Catenin Gamma (Plakoglobin) Jup Antibody (Monoclonal, 15F11) catalog # MA1012. Tested in IHC, ICC, WB applications. This antibody reacts with Bovine, Human.

Product Specifications

Background

Junction Plakoglobin (JUP), also knows as catenin gamma, is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions. It is a component of the cadherin-catenin complex, which is predominantly localized where actin filaments anchor in adherens junctions of epithelial cells. The human plakoglobin gene localizes on chromosome 17q21. Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.

Synonyms

Junction plakoglobin; Jup

Gene Name

JUP

Gene ID

Human (3728), Mouse (16480), Rat (81679)

UniProt

Q6P0K8

Host

Mouse

Reactivity

Bovine, Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

Recombinant chicken plakoglobin.

Clonality

Monoclonal

Clone

Clone: 15F11

Tissue Specificity

Smooth muscle, and tissues containing significant amounts of smooth muscle.

Applications

IHC, ICC, WB

Field of Research

Actin, etc., Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction

Purification

Ascites

Concentration

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Form

Lyophilized

Reconstitution

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Function

Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity) . .

References & Citations

1. Aberle, H.; Bierkamp, C.; Torchard, D.; Serova, O.; Wagner, T.; Natt, E.; Wirsching, J.; Heidkamper, C.; Montagna, M.; Lynch, H. T.; Lenoir, G. M.; Scherer, G.; Feunteun, J.; Kemler, R. : The human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers. Proc. Nat. Acad. Sci. 92: 6384-6388, 1995. 2. Kolligs, F. T.; Kolligs, B.; Hajra, K. M.; Hu, G.; Tani, M.; Cho, K. R.; Fearon, E. R. : Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin. Genes Dev. 14: 1319-1331, 2000.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

81801 MW

Observed Molecular Weight

82 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Junction plakoglobin

Subcellular Location

Cell junction, adherens junction . Cell junction, desmosome . Cytoplasm, cytoskeleton . Membrane ; Peripheral membrane protein . Cytoplasmic in a soluble and membrane-associated form. .

Sequence Similarities

Belongs to the beta-catenin family.

Protein Name

Junction plakoglobin

Isotype

Mouse IgG1

Contents

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.

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