Anti-GIMAP5 Antibody Picoband® APC Conjugated

This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene.

GIMAP5; IAN4L1; IAN5; IMAP3; GTPase IMAP family member 5; Immune-associated nucleotide-binding protein 5; Immunity-associated nucleotide 4-like 1 protein; Immunity-associated nucleotide 5 protein; IAN-5; hIAN5; Immunity-associated protein 3

E.coli-derived human GIMAP5 recombinant protein (Position: M1-E240) . Human GIMAP5 shares 61.7% and 57.9% amino acid (aa) sequence identity with mouse and rat GIMAP5, respectively.

1. Barnes, M. J., Aksoylar, H., Krebs, P., Bourdeau, T., Arnold, C. N., Xia, Y., Khovananth, K., Engel, I., Sovath, S., Lampe, K., Laws, E., Saunders, A., Butcher, G. W., Kronenberg, M., Steinbrecher, K., Hildeman, D., Grimes, H. L., Beutler, B., Hoebe, K. Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice. J. Immun. 184: 3743-3754, 2010. 2. Daheron, L., Zenz, T., Siracusa, L. D., Brenner, C., Calabretta, B. Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activity. Nucleic Acids Res. 29: 1308-1316, 2001. 3. Drzewiecki, K., Choi, J., Brancale, J., Leney-Greene, M. A., Sari, S., Dalgic, B., Aksu, A. U., Sahin, G. E., Ozen, A., Baris, S., Karakoc-Aydiner, E., Jain, D., and 10 others. GIMAP5 maintains liver endothelial cell homeostasis and prevents portal hypertension. J. Exp. Med. 218: e20201745, 2021.