Anti-MARCKS Antibody Picoband® HRP Conjugated

The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.

MARCKS; MACS; PRKCSL; Myristoylated alanine-rich C-kinase substrate; MARCKS; Protein kinase C substrate, 80 kDa protein, light chain; 80K-L protein; PKCSL

1. Blackshear, P. J. The MARCKS family of cellular protein kinase C substrates. J. Biol. Chem. 268: 1501-1504, 1993. 2. Blackshear, P. J., Tuttle, J. S., Oakey, R. J., Seldin, M. F., Chery, M., Philippe, C., Stumpo, D. J. Chromosomal mapping of the human (MACS) and mouse (Macs) genes encoding the MARCKS protein. Genomics 14: 168-174, 1992. 3. Boyle, J. M., Hey, Y., Myers, K., Stern, P. L., Grzeschik, F.-H., Ikehara, Y., Misumi, Y., Fox, M. Regional localization of a trophoblast antigen-related sequence and 16 other sequences to human chromosome 6q using somatic cell hybrids. Genomics 12: 693-698, 1992.