Anti-HOXB6 Antibody Picoband® HRP Conjugated

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer.

A synthetic peptide corresponding to a sequence at the C-terminus of human HOXB6. Human HOXB6 shares 95.5% amino acid (aa) sequence identity with mouse HOXB6.

1. Apiou, F., Flagiello, D., Cillo, C., Malfoy, B., Poupon, M.-F., Dutrillaux, B. Fine mapping of human HOX gene clusters. Cytogenet. Cell Genet. 73: 114-115, 1996. 2. Kaur, S., Singh, G., Stock, J. L., Schreiner, C. M., Kier, A. B., Yager, K. L., Mucenski, M. L., Scott, W. J., Jr., Potter, S. S. Dominant mutation of the murine Hox-2.2 gene results in developmental abnormalities. J. Exp. Zool. 264: 323-336, 1992.