Anti-HAND1 Antibody Picoband® APC Conjugated

The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation.

HAND1; BHLHA27; EHAND; Heart- and neural crest derivatives-expressed protein 1; Class A basic helix-loop-helix protein 27; bHLHa27; Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; eHAND

A synthetic peptide corresponding to a sequence at the C-terminus of human HAND1. Human HAND1 shares 90% and 93.8% amino acid (aa) sequence identity with mouse and rat HAND1, respectively.

1. Cserjesi, P., Brown, D., Lyons, G. E., Olson, E. N. Expression of the novel basic helix-loop-helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse development. Dev. Biol. 170: 664-678, 1995. 2. Firulli, A. B., McFadden, D. G., Lin, Q., Srivastava, D., Olson, E. N. Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Nature Genet. 18: 266-270, 1998. 3. Knofler, M., Meinhardt, G., Bauer, S., Loregger, T., Vasicek, R., Bloor, D. J., Kimber, S. J., Husslein, P. Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domains. Biochem J. 361: 641-651, 2002.