Anti-HTR3E Antibody Picoband®

This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described.

1. Kapeller, J., Houghton, L. A., Monnikes, H., Walstab, J., Moller, D., Bonisch, H., Burwinkel, B., Autschbach, F., Funke, B., Lasitschka, F., Gassler, N., Fischer, C., and 10 others. First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome. Hum. Molec. Genet. 17: 2967-2977, 2008. 2. Karnovsky, A. M., Gotow, L. F., McKinley, D. D., Piechan, J. L., Ruble, C. L., Mills, C. J., Schellin, K. A. B., Slightom, J. L., Fitzgerald, L. R., Benjamin, C. W., Roberds, S. L. A cluster of novel serotonin receptor 3-like genes on human chromosome 3. Gene 319: 137-148, 2003. 3. Niesler, B., Frank, B., Kapeller, J., Rappold, G. A. Cloning, physical mapping and expression analysis of the human 5-HT (3) serotonin receptor-like genes HTR3C, HTR3D and HTR3E. Gene 310: 101-111, 2003.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.