Anti-PRDM6 Antibody Picoband® Biotin Conjugated
Product Specifications
Background
The protein encoded by this gene is a transcriptional repressor and a member of the PRDM family. Family members contain a PR domain and multiple zinc-finger domains. The encoded protein is involved in regulation of vascular smooth muscle cells (VSMC) contractile proteins. Mutations in this gene result in patent ductus arteriosus 3 (PDA3) .
Synonyms
PRDM6; PFM3; Putative histone-lysine N-methyltransferase PRDM6; EC 2.1.1.-; PR domain zinc finger protein 6; PR domain-containing protein 6
Gene Name
PRDM6
Gene ID
93166
UniProt
Q9NQX0
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human PRDM6 recombinant protein (Position: R165-R452) . Human PRDM6 shares 97.2% amino acid (aa) sequence identity with mouse PRDM6.
Clonality
Polyclonal
Applications
WB, IHC, ELISA
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Hartz, P. A. Personal Communication. Baltimore, Md. 6/16/2016. 2. Li, N., Subrahmanyan, L., Smith, E., Yu, X., Zaidi, S., Choi, M., Mane, S., Nelson-Williams, C., Behjati, M., Kazemi, M., Hashemi, M., Fathzadeh, M., and 12 others. Mutations in the histone modifier PRDM6 are associated with isolated nonsyndromic patent ductus arteriosus. Am. J. Hum. Genet. 98: 1082-1091, 2016. Note: Erratum: Am. J. Hum. Genet. 99: 1000 only, 2016. 3. Lynch, H. T., Grissom, R. L., Magnuson, C. R., Krush, A. Patent ductus arteriosus: study of two families. JAMA 194: 135-118, 1965.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.
Calculated Molecular Weight
61 kDa
Gene Name Synonym
PR/SET domain 6
Protein Name
Putative histone-lysine N-methyltransferase PRDM6
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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