Anti-RIM1/RIMS1 Antibody Picoband®

The protein encoded by this gene is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. This gene also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Multiple transcript variants encoding different isoforms have been described for this gene.

RIMS1; KIAA0340; RAB3IP2; RIM1; Nbla00761; Regulating synaptic membrane exocytosis protein 1; Rab-3-interacting molecule 1; RIM 1; Rab-3-interacting protein 2

1. Barragan, I., Marcos, I., Borrego, S., Antinolo, G. Molecular analysis of RIM1 in autosomal recessive retinitis pigmentosa. Ophthalmic Res. 37: 89-93, 2005. 2. Betz, A., Thakur, P., Junge, H. J., Ashery, U., Rhee, J.-S., Scheuss, V., Rosenmund, C., Rettig, J., Brose, N. Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming. Neuron 30: 183-196, 2001. 3. Castillo, P. E., Schoch, S., Schmitz, F., Sudhof, T. C., Malenka, R. C. RIM1-alpha is required for presynaptic long-term potentiation. Nature 415: 327-330, 2002.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.