Anti-RARRES3/PLAAT4 Antibody Picoband® APC Conjugated

Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator.

PLAAT4; RARRES3; RIG1; TIG3; Phospholipase A and acyltransferase 4; EC 2.3.1.-; EC 3.1.1.32; EC 3.1.1.4; HRAS-like suppressor 4; HRSL4; RAR-responsive protein TIG3; Retinoic acid receptor responder protein 3; Retinoid-inducible gene 1 protein; Tazarotene-induced gene 3 protein

1. DiSepio, D., Ghosn, C., Eckert, R. L., Deucher, A., Robinson, N., Duvic, M., Chandraratna, R. A. S., Nagpal, S. Identification and characterization of a retinoid-induced class II tumor suppressor/growth regulatory gene. Proc. Nat. Acad. Sci. 95: 14811-14815, 1998. 2. Uyama, T., Jin, X.-H., Tsuboi, K., Tonai, T., Ueda, N. Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. Biochim. Biophys. Acta 1791: 1114-1124, 2009.