Anti-ETV2 Antibody Picoband® HRP Conjugated

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of endothelial cell differentiation; and positive regulation of mesoderm development. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; and hemolymphoid system. Human ortholog (s) of this gene implicated in limb ischemia. Orthologous to human ETV2 (ETS variant transcription factor 2) .

1. Basel-Salmon, L., Ruhrman-Shahar, N., Barel, O., Hagari, O., Marek-Yagel, D., Azulai, N., Bazak, L., Svirsky, R., Reznik-Wolf, H., Lidzbarsky, G. A., Shohat, M. Biallelic variants in ETV2 in a family with congenital heart defects, vertebral abnormalities and preaxial polydactyly. Europ. J. Med. Genet. 64: 104124, 2021. 2. Brown, T. A., McKnight, S. L. Specificities of protein-protein and protein-DNA interaction of GABP-alpha and two newly defined ets-related proteins. Genes Dev. 6: 2502-2512, 1992. 3. De Haro, L., Janknecht, R. Cloning of the murine ER71 gene (Etsrp71) and initial characterization of its promoter. Genomics 85: 493-502, 2005.