Anti-ETV2 Antibody Picoband® Biotin Conjugated
Product Specifications
Background
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of endothelial cell differentiation; and positive regulation of mesoderm development. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; and hemolymphoid system. Human ortholog (s) of this gene implicated in limb ischemia. Orthologous to human ETV2 (ETS variant transcription factor 2) .
Synonyms
ETV2; ER71; ETSRP71; ETS translocation variant 2; Ets-related protein 71
Gene Name
ETV2
Gene ID
14008
UniProt
P41163
Host
Rabbit
Reactivity
Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived mouse ETV2 recombinant protein (Position: M1-Q335) . Mouse ETV2 shares 67.4% amino acid (aa) sequence identity with human ETV2.
Clonality
Polyclonal
Applications
WB, IHC, ELISA
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Basel-Salmon, L., Ruhrman-Shahar, N., Barel, O., Hagari, O., Marek-Yagel, D., Azulai, N., Bazak, L., Svirsky, R., Reznik-Wolf, H., Lidzbarsky, G. A., Shohat, M. Biallelic variants in ETV2 in a family with congenital heart defects, vertebral abnormalities and preaxial polydactyly. Europ. J. Med. Genet. 64: 104124, 2021. 2. Brown, T. A., McKnight, S. L. Specificities of protein-protein and protein-DNA interaction of GABP-alpha and two newly defined ets-related proteins. Genes Dev. 6: 2502-2512, 1992. 3. De Haro, L., Janknecht, R. Cloning of the murine ER71 gene (Etsrp71) and initial characterization of its promoter. Genomics 85: 493-502, 2005.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.
Calculated Molecular Weight
37 kDa
Gene Name Synonym
Ets variant 2
Protein Name
ETS translocation variant 2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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