Anti-Synaptotagmin-12/SYT12 Antibody Picoband®

This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Studies of the orthologous gene in rat have shown that the encoded protein selectively modulates spontaneous synaptic-vesicle exocytosis and may also be involved in regulating calcium independent secretion in nonneuronal cells. Alternative splicing results in multiple transcript variants. The gene has previously been referred to as synaptotagmin XI but has been renamed synaptotagmin XII to be standard with mouse and rat official nomenclature.

E.coli-derived human Synaptotagmin-12/SYT12 recombinant protein (Position: Q63-R410) . Human Synaptotagmin-12/SYT12 shares 94.5% and 95.7% amino acid (aa) sequence identity with mouse and rat Synaptotagmin-12/SYT12, respectively.

1. Craxton, M. Genomic analysis of synaptotagmin genes. Genomics 77: 43-49, 2001. 2. Fernandez-Chacon, R., Konigstorfer, A., Gerber, S. H., Garcia, J., Matos, M. F., Stevens, C. F., Brose, N., Rizo, J., Rosenmund, C., Sudhof, T. C. Synaptotagmin I functions as a calcium regulator of release probability. Nature 410: 41-49, 2001. 3. Itoh, Y., Esaki, T., Kaneshige, M., Suzuki, H., Cook, M., Sokoloff, L., Cheng, S.-Y., Nunez, J. Brain glucose utilization in mice with a targeted mutation in the thyroid hormone alpha or beta receptor gene. Proc. Nat. Acad. Sci. 98: 9913-9918, 2001.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.