Anti-GALC Antibody Picoband® HRP Conjugated

This gene encodes a lysosomal protein which hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Mutations in this gene have been associated with Krabbe disease, also known as globoid cell leukodystrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

1. Cannizzaro, L. A., Chen, Y. Q., Rafi, M. A., Wenger, D. A. Regional mapping of the human galactocerebrosidase gene (GALC) to 14q31 by in situ hybridization. Cytogenet. Cell Genet. 66: 244-245, 1994. 2. Chen, Y. Q., Rafi, M. A., de Gala, G., Wenger, D. A. Cloning and expression of cDNA encoding human galactocerebrosidase, the enzyme deficient in globoid cell leukodystrophy. Hum. Molec. Genet. 2: 1841-1845, 1993. 3. Chen, Y. Q., Wenger, D. A. Galactocerebrosidase from human urine: purification and partial characterization. Biochim. Biophys. Acta 1170: 53-61, 1993.