Anti-PXDN Antibody Picoband® PE Conjugated

This gene encodes a heme-containing peroxidase that is secreted into the extracellular matrix. It is involved in extracellular matrix formation, and may function in the physiological and pathological fibrogenic response in fibrotic kidney. Mutations in this gene cause corneal opacification and other ocular anomalies, and also microphthalmia and anterior segment dysgenesis.

PXDN; KIAA0230; MG50; PRG2; VPO; VPO1; Peroxidasin homolog; EC 1.11.1.7; Melanoma-associated antigen MG50; Vascular peroxidase 1; p53-responsive gene 2 protein

1. Cheng, G., Salerno, J. C., Cao, Z., Pagano, P. J., Lambeth, J. D. Identification and characterization of VPO1, a new animal heme-containing peroxidase. Free Radic. Biol. Med. 45: 1682-1694, 2008. 2. Choi, A., Lao, R., Ling-Fung Tang, P., Wan, E., Mayer, W., Bardakjian, T., Shaw, G. M., Kwok, P., Schneider, A., Slavotinek, A. Novel mutations in PXDN cause microphthalmia and anterior segment dysgenesis. Europ. J. Hum. Genet. 23: 337-341, 2015. 3. Horikoshi, N., Cong, J., Kley, N., Shenk, T. Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene. Biochem. Biophys. Res. Commun. 261: 864-869, 1999.