Anti-GGN Antibody Picoband® HRP Conjugated

This gene is a germ cell-specific gene that encodes proteins that interact with POG (proliferation of germ cells) . Alternatively spliced transcript variants of a similar mouse gene encode at least three different proteins, namely gametogenetin protein 1a, gametogenetin protein 2, and gametogenetin protein 3, which show a perinuclear, cytoplasmic, and nucleolar localization, respectively. These proteins regulate the localization of POG and may play a role in spermatogenesis.

A synthetic peptide corresponding to a sequence at the C-terminus of human GGN. Human GGN shares 93.8% amino acid (aa) sequence identity with both mouse and rat GGN.

1. Celse, T., Cazin, C., Mietton, F., Martinez, G., Martinez, D., Thierry-Mieg, N., Septier, A., Guillemain, C., Beurois, J., Clergeau, A., Mustapha, S. F. B., Kharouf, M., and 31 others. Genetic analyses of a large cohort of infertile patients with globozoospermia, DPY19L2 still the main actor, GGN confirmed as a guest player. Hum. Genet. 140: 43-57, 2021. 2. Jamsai, D., Bianco, D. M., Smith, S. J., Merriner, D. J., Ly-Huynh, J. D., Herlihy, A., Niranjan, B., Gibbs, G. M., O'Bryan, M. K. Characterization of gametogenetin 1 (GGN1) and its potential role in male fertility through the interaction with the ion channel regulator, cysteine-rich secretory protein 2 (CRISP2) in the sperm tail. Reproduction 135: 751-759, 2008. 3. Jamsai, D., Sarraj, M. A., Merriner, D. J., Drummond, A. E., Jones, K. T., McLachlan, R. I., O'Bryan, M. K. GGN1 in the testis and ovary and its variance within the Australian fertile and infertile male population. Int. J. Androl. 34: 624-632, 2011.