Anti-SPO11 Antibody Picoband® HRP Conjugated

Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described.

1. Baudat, F., Manova, K., Yuen, J. P., Jasin, M., Keeney, S. Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking Spo11. Molec. Cell 6: 989-998, 2000. 2. Garcia, V., Phelps, S. E. L., Gray, S., Neale, M. J. Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1. Nature 479: 241-244, 2011. 3. Guillon, H., Baudat, F., Grey, C., Liskay, R. M., de Massy, B. Crossover and noncrossover pathways in mouse meiosis. Molec. Cell 20: 563-573, 2005.