Anti-SPO11 Antibody Picoband® Biotin Conjugated
Product Specifications
Background
Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described.
Synonyms
SPO11; Meiotic recombination protein SPO11; EC 5.6.2.2; Cancer/testis antigen 35; CT35
Gene Name
SPO11
Gene ID
23626
UniProt
Q9Y5K1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human SPO11 recombinant protein (Position: R40-D326) . Human SPO11 shares 83.3% amino acid (aa) sequence identity with mouse SPO11.
Clonality
Polyclonal
Applications
WB, IHC, ELISA
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Baudat, F., Manova, K., Yuen, J. P., Jasin, M., Keeney, S. Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking Spo11. Molec. Cell 6: 989-998, 2000. 2. Garcia, V., Phelps, S. E. L., Gray, S., Neale, M. J. Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1. Nature 479: 241-244, 2011. 3. Guillon, H., Baudat, F., Grey, C., Liskay, R. M., de Massy, B. Crossover and noncrossover pathways in mouse meiosis. Molec. Cell 20: 563-573, 2005.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.
Calculated Molecular Weight
45 kDa
Gene Name Synonym
SPO11 initiator of meiotic double strand breaks
Protein Name
Meiotic recombination protein SPO11
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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