Anti-GP6 Antibody Picoband® HRP Conjugated
Product Specifications
Background
Enables collagen binding activity and collagen receptor activity. Acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway; peptidyl-tyrosine phosphorylation; and platelet aggregation. Located in cell surface and plasma membrane. Is expressed in bone marrow; femur; liver; and spleen. Human ortholog (s) of this gene implicated in blood platelet disease (multiple) ; coronary artery disease (multiple) ; and type 2 diabetes mellitus. Orthologous to human GP6 (glycoprotein VI platelet) .
Synonyms
GP6; Platelet glycoprotein VI; GPVI; Glycoprotein 6
Gene Name
GP6
Gene ID
243816
UniProt
P0C191
Host
Rabbit
Reactivity
Mouse
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of mouse GP6. Mouse GP6 shares 75% amino acid (aa) sequence identity with human GP6.
Clonality
Polyclonal
Applications
WB, IHC, ELISA
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Boilard, E., Nigrovic, P. A., Larabee, K., Watts, G. F. M., Coblyn, J. S., Weinblatt, M. E., Massarotti, E. M., Remold-O'Donnell, E., Farndale, R. W., Ware, J., Lee, D. M. Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science 327: 580-583, 2010. 2. Dumont, B., Lasne, D., Rothschild, C., Bouabdelli, M., Ollivier, V., Oudin, C., Ajzenberg, N., Grandchamp, B., Jandrot-Perrus, M. Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations. Blood 114: 1900-1903, 2009. 3. zumi, Y., Uchiyama, T., Takayama, H. Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI. Biochem. Biophys. Res. Commun. 277: 27-36, 2000.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.
Calculated Molecular Weight
35 kDa
Gene Name Synonym
Glycoprotein 6 platelet
Protein Name
Platelet glycoprotein VI
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4.
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