Anti-EPHA4 Antibody Picoband® HRP Conjugated

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene.

EPHA4; HEK8; SEK; TYRO1; Ephrin type-A receptor 4; EC 2.7.10.1; EPH-like kinase 8; EK8; hEK8; Tyrosine-protein kinase TYRO1; Tyrosine-protein kinase receptor SEK

A synthetic peptide corresponding to a sequence at the C-terminus of human EPHA4. Human EPHA4 shares 100% amino acid (aa) sequence identity with mouse EPHA4.

1. Cowan, C. A., Yokoyama, N., Bianchi, L. M., Henkemeyer, M., Fritzsch, B. EphB2 guides axons at the midline and is necessary for normal vestibular function. Neuron 26: 417-430, 2000. 2. Dottori, M., Hartley, L., Galea, M., Paxinos, G., Polizzotto, M., Kilpatrick, T., Bartlett, P. F., Murphy, M., Kontgen, F., Boyd, A. W. EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract. Proc. Nat. Acad. Sci. 95: 13248-13253, 1998. 3. Fox, G. M., Holst, P. L., Chute, H. T., Lindberg, R. A., Janssen, A. M., Basu, R., Welcher, A. A. cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases. Oncogene 10: 897-905, 1995.