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Anti-IQSEC2 Antibody Picoband® HRP Conjugated

Product Specifications

Background

This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked cognitive disability. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Synonyms

IQSEC2; KIAA0522; IQ motif and SEC7 domain-containing protein 2

Gene Name

IQSEC2

Gene ID

23096

UniProt

Q5JU85

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human IQSEC2 recombinant protein (Position: A122-M1396) . Human IQSEC2 shares 98.2% amino acid (aa) sequence identity with mouse IQSEC2.

Clonality

Polyclonal

Applications

WB, IHC, ELISA

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. de Vries, B. B. A., Breedveld, G. J., Deelen, W. H., Niermeijer, M. F., Heutink, P., Breuning, M. H. Another family with nonspecific X-linked mental retardation (MRX78) maps to Xp11.4-p11.23. Am. J. Med. Genet. 111: 443-445, 2002. Note: Erratum: Am. J. Med. Genet. 113: 391 only 2002. 2. Filippova, G. N., Cheng, M. K., Moore, J. M., Truong, J.-P., Hu, Y. J., Nguyen, D. K., Tsuchiya, K. D., Disteche, C. M. Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development. Dev. Cell 8: 31-42, 2005. 3. Gedeon, A., Kerr, B., Mulley, J., Turner, G. Pericentromeric genes for non-specific X-linked mental retardation (MRX) . Am. J. Med. Genet. 51: 553-564, 1994.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.

Calculated Molecular Weight

163 kDa

Gene Name Synonym

IQ motif and Sec7 domain ArfGEF 2

Protein Name

IQ motif and SEC7 domain-containing protein 2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4.

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